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Best HRT Services 2025

Looking for the best HRT options? We compare and review top online hormone replacement therapy clinics to help you find safe, effective treatment tailored to your needs. Whether you’re exploring bioidentical hormones, estrogen patches, or progesterone creams, we break down the best options for women navigating the transition to menopause.

Last updated: September 2025

Winona
9.2  
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HSA/FSA-eligible compounded treatments
  • Treatments made custom for your body
  • Easy medical intake to see if you qualify
  • Fast easy & convenient menopause symptom care
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Pros
  • prosA wide array of treatments available
  • prosTreatments customized to the patient
  • prosThe patient portal makes order monitoring easy
  • prosUser-friendly interface and a quiz
  • prosEverything is online-based
Cons
  • consRegistering an account is necessary
  • consNo clear mention of working hours
Wisp
9.1  
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HSA and FSA eligible treatments
  • Unlimited access to experts for 3 months
  • Same-day pickup or free home delivery
  • Trusted by 1.5 million+ nationwide
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Pros
  • prosPersonalized menopause/HRT care
  • prosSame-day pickup or discreet delivery
  • prosHSA/FSA eligible
  • pros3 months expert support
  • prosFast, empathetic telehealth
Cons
  • consNo in-person visits
  • consLimited non-hormonal tracking
  • consPost-consult pricing not so transparent
Hone Health
8.8  
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Save over $100 on 40+ biomarker test
  • Creams, inserts, injections, & tablets
  • BioMarker test, consult, & treatment included
  • Over 5K 5-star Reviews and 4.9 on Trustpilot
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Pros
  • prosPersonalized, data-driven hormone care
  • prosConvenient virtual visits and at-home testing
  • prosOngoing monitoring with regular re-evaluations
  • prosCare led by licensed physicians for safety
  • prosDiscreet shipping and privacy-focused service
Cons
  • consMedication costs are separate from membership fees
  • consBasic plan lacks lab testing and provider consultations
Sesame
8.5  
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Transparent, upfront pricing
  • Find relief from menopause symptoms
  • Same-day treatment for perimenopause
  • Medication options for your goals and budget
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Pros
  • prosTransparent, affordable pricing at $99/month
  • prosLicensed providers with menopause expertise
  • prosIncludes labs and follow-up care
  • prosDiscreet telehealth consultations from home
  • prosDiscreet telehealth consultations from home
Cons
  • consDoesn’t accept insurance directly
  • consLimited add-ons
  • consMedication costs may vary
  • consBest suited to mild-to-moderate HRT cases
PlushCare
8.2  
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Get 30 days of free membership
  • Treatments sent to your local pharmacy
  • 1M+ Members treated
  • Insurance accepted, but not required
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Pros
  • prosLicensed physicians with a lot of experience
  • prosReceive prescriptions for HRT
  • prosEasy to use and entirely online-based
  • prosSchedule an appointment in 15 minutes
  • prosUser dashboard to track current prescriptions
Cons
  • consNeed a doctors consultation to do anything
  • consNo live chat available
Our Top Choice
*Featured prices and terms can be updated. Free offers may include additional terms. The above shall not be considered as medical, health or professional advice.

What Is Hormone Replacement Therapy (HRT)?

Hormone Replacement Therapy (HRT) is a clinically proven treatment that helps women going through perimenopause or menopause manage hormonal imbalances. As estrogen and progesterone levels decline with age, many women experience symptoms like:

  • Hot flashes and night sweats
  • Brain fog and difficulty concentrating
  • Mood swings and anxiety
  • Sleep disturbances and fatigue
  • Vaginal dryness and painful sex
  • Weight gain and slowed metabolism
  • Low libido

HRT helps by restoring these hormones to more balanced levels. Depending on your health history and symptoms, HRT may involve estrogen pills, bioidentical hormone replacement therapy creams, estradiol patches, progesterone pills, topical estrogen, or hormone pellets.

It’s also common for women to explore natural estrogen supplements, wild yam cream, or estriol face cream for both symptom relief and anti-aging benefits. We evaluate both traditional HRT medications like Premarin®, and modern, convenient online hormone therapy services that offer personalized treatment plans from licensed providers.

Top Recommended HRT Providers 2025

Types of HRT You May Consider:

  • Estrogen therapy (oral pills, estrogen patch, or topical estrogen creams)
  • Progesterone supplements (capsules or progesterone cream)
  • Combination estrogen + progesterone therapies
  • Bioidentical hormones (custom-compounded formulations)
  • Vaginal estrogen creams, rings, or tablets for dryness and local relief
  • Hormone pellets are inserted under the skin for slow-release dosing

Today, many online HRT clinics offer access to bioidentical hormone therapy and lab testing from the comfort of your home. These services typically start with a perimenopause quiz, hormone panel, or telehealth consult to assess your symptoms and determine if you’re a candidate for HRT for perimenopause or menopause hormone therapy.

Our top picks for September 2025

Is HRT Right for You?

If you’re wondering, “Do I need hormone replacement therapy?”, you’re not alone. HRT is a powerful treatment option — but it’s not for everyone. It’s typically recommended for perimenopausal or postmenopausal women who are experiencing moderate to severe menopause symptoms, such as:

  • Persistent hot flashes and night sweats
  • Mood swings, anxiety, or depression
  • Low libido or vaginal dryness
  • Menopause weight gain or slowed metabolism
  • Difficulty sleeping or menopause fatigue

Women with early menopause, surgical menopause, or those facing vasomotor symptoms may also benefit from bioidentical hormone therapy or traditional HRT options like estradiol cream, Premarin vaginal cream, or progesterone pills.

Take the Guesswork Out

Still unsure if HRT therapy is right for you? Many of the online HRT providers we review offer simple tools like:

  • A perimenopause quiz
  • Personalized medical consultations
  • Hormone panel testing (estrogen, progesterone, testosterone, DHEA, etc.)
  • Access to NAMS Certified Menopause Practitioners near you

These platforms help determine if you’re a candidate for HRT for perimenopause or menopause hormone therapy, and which type of estrogen supplement or topical estrogen cream would work best for your symptoms and lifestyle.

How Does HRT Work? Understanding the Benefits

Hormone Replacement Therapy (HRT) works by supplementing your body with hormones that naturally decline during perimenopause and menopause, primarily estrogen, progesterone, and sometimes testosterone.

Common HRT Formats:

  • Pills – e.g., estradiol tablets, Premarin pills, or progesterone pills
  • Patches – like the estradiol patch or topical estrogen patches
  • Creams – including estriol cream, bioidentical estrogen face creams, and vaginal estrogen creams
  • Pellets – long-acting hormone pellet therapy inserted under the skin
  • Injections – less common, but some opt for testosterone injections or bioidentical hormone shots

HRT isn’t just about symptom relief — it’s about regaining vitality, energy, and control over your changing body. Whether you’re researching online HRT therapy, bioidentical hormones near me, or comparing estradiol creams, the key is finding the right type and dosage for your unique needs.

Types of Hormone Therapy & How to Choose the Right One

Not all hormone replacement therapy (HRT) options are the same, and that’s a good thing. The most effective HRT for perimenopause or menopause is highly personalized based on your age, symptoms, risk factors, and preferences. Choosing the correct form of HRT can make all the difference in how your body responds.

Main Types of HRT:

1. Systemic Estrogen Therapy

This is the most commonly prescribed type and can be delivered as:

  • Pills (e.g., estradiol, Premarin)
  • Patches (e.g., estradiol patch)
  • Gels and sprays
  • Injections or pellets

Systemic HRT is especially effective for whole-body symptoms like hot flashes, night sweats, and menopause-related mood swings.

2. Vaginal Estrogen Therapy

For localized symptoms like vaginal dryness, itching, and painful sex after menopause, low-dose vaginal estrogen may be more appropriate:

  • Creams (e.g., Premarin vaginal cream, estradiol vaginal cream)
  • Rings (e.g., Estring vaginal ring)
  • Tablets (e.g., Vagifem)

These options deliver estrogen directly to vaginal tissue with minimal systemic absorption — ideal for women who want relief from menopause vaginal dryness without full-body HRT.

3. Bioidentical Hormone Replacement Therapy (BHRT)

Derived from plant sources and designed to be chemically identical to hormones produced in the human body, bioidentical hormone replacement therapy is available through:

  • Custom-compounded creams
  • Pellets inserted under the skin
  • Tablets or troches

Popular options include Biote, Alloy, and services that offer online BHRT consultations. While BHRT is growing in popularity, it’s essential to choose a provider with experience and appropriate lab testing to avoid over- or under-dosing.

Our top picks for September 2025

Final Thoughts: Choosing the Right Hormone Replacement Therapy Provider

Whether you’re navigating perimenopause symptoms like brain fog, mood swings, and weight gain, or looking to ease menopause-related hot flashes, there’s no shortage of options today. Still, not all HRT clinics, online hormone therapy services, or bioidentical hormone replacement providers are created equal.

We help you cut through the noise by reviewing and comparing the best online HRT providers for women. We look at pricing, treatment plans, reviews, delivery options, insurance eligibility, and access to licensed hormone doctors.

Many services offer:

  • Access to estradiol creams, progesterone pills, and hormone pellets for women
  • Convenient telemedicine consultations with menopause specialists near you
  • At-home testing and custom-compounded bioidentical hormones
  • Popular treatments like Biote, Winona HRT, Alloy estriol cream, MIDI, and more

From natural hormone replacement therapy to FDA-approved estrogen treatments, we break down what you need to know — so you can choose the best service for your symptoms, goals, and budget.

Frequently Asked Questions

Q. What is hormone replacement therapy (HRT)?
A. Hormone Replacement Therapy (HRT) is a medical treatment that supplements the body with estrogen, progesterone, or both to relieve common perimenopausal and menopausal symptoms like hot flashes, night sweats, and mood changes.

Q. Who is a good candidate for HRT?
A. HRT is ideal for women under 60 or within 10 years of menopause who are experiencing moderate to severe symptoms and do not have a history of hormone-sensitive conditions.

Q. Are there different types of HRT and delivery methods?
A. Yes, HRT comes in many forms ,including oral tablets, transdermal patches, vaginal rings, creams, gels, and hormone pellets. Each option targets different symptoms and lifestyle preferences.

Q. What are the risks associated with HRT?
A. Risks may include a slightly increased chance of blood clots, stroke, heart disease, and breast cancer—especially if started later in life or taken long-term without medical supervision.

Q. What is bioidentical hormone therapy, and is it safer?
A. Bioidentical hormone therapy uses hormones identical to those naturally produced by the body, often compounded for personalized dosing. While marketed as “natural,” they carry the same risks and benefits as traditional HRT.

Q. When is the best time to start HRT?
A. The best time to start HRT is within 10 years of menopause onset, typically before age 60, to maximize benefits and minimize health risks.

Q. Is HRT safe for women with a history of breast cancer or blood clots?
A. HRT is generally not recommended for women with a history of hormone-sensitive cancer, stroke, or clotting disorders. Non-hormonal treatments may be safer alternatives.

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